排序方式: 共有67条查询结果,搜索用时 187 毫秒
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Timms GH Boot JR Broadmore RJ Carney SL Cooper J Findlay JD Gilmore J Mitchell S Moore NA Pullar I Sanger GJ Tomlinson R Tree BB Wedley S 《Bioorganic & medicinal chemistry letters》2004,14(10):2469-2472
Incorporation of an SRI (serotonin reuptake inhibitor) pharmacophore into a selective 5-HT(1D) agonist has led to the discovery of a molecule having both 5-HT(1D) antagonist and SRI activity. RPS methodology was used to develop the SAR and identify potential approaches to reduce unwanted adrenergic alpha 1 and dopamine D(2) cross-reactivities. 相似文献
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毛果杨NADP-苹果酸酶基因家族分析 总被引:1,自引:0,他引:1
本文分析C3树木毛果杨NADP-苹果酸酶(Populus trichocarpa NADP—malic enzyme,PtNADP-ME)基因家族及其表达特性。NADP—MEN源性检索表明,毛果杨基因组上存在5个PtNADP—ME基因,其中PtNADP-ME4编码区不完整。RT-PCRE及DNA测序结果表明,PtNADP-ME家族5个基因均转录表达。进化树构建显示,毛果杨PtNADP-ME家族5个成员分属于植物NADP—ME家族的3个进化分枝。半定量RT-PCR表明,5个PtNAP-ME家族基因没有明显的组织特异表达模式。然而,不同的PtNADP-ME基因转录表达对NaCI、PEG及甘露醇3种逆境胁迫应答与否以及应答方式存在明显的差异。 相似文献
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A. Medina P. R. F. Bell J. D. Briggs J. J. Brown A. Fine A. F. Lever J. J. Morton A. M. Paton J. I. S. Robertson M. Tree M. A. Waite R. Weir J. Winchester 《BMJ (Clinical research ed.)》1972,4(5842):694-696
Circulating levels of renin, angiotensin I, and angiotensin II were increased in six patients with chronic renal failure and hypertension uncontrolled by dialysis and hypotensive drugs. Lower and often normal levels were found in 10 patients whose blood pressure was controlled by dialysis treatment. For a variety of reasons all patients were subjected to bilateral nephrectomy. The logarithm of the decrease in plasma concentrations of renin and angiotensin II was significantly related to the fall of blood pressure after operation. Plasma renin concentration correlated significantly with blood angiotensin I concentration and with plasma angiotensin II in samples taken before and after nephrectomy. Renin, angiotensin I, and angiotensin II were measurable in samples of blood taken 48 hours or more after the operation. 相似文献
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Magdalena Remisiewicz Anthony J. Tree Les G. Underhill P. Barry Taylor 《Journal of Ornithology》2010,151(2):429-441
Immature migrant waders have more complex patterns of primary moult than adults, but these have been described only fragmentarily.
The Wood Sandpiper Tringa glareola breeds in the taiga region of the Palearctic and part of the population migrates to southern Africa. We selected this population
for a study of the primary moult strategies of an immature wader. After analysing the moult formulae of 674 immatures, we
discuss potential factors that influence the choice of moult strategy. All moulters replaced two to six outer primaries; 91%
moulted four or five. We used the Underhill–Zucchini model to estimate the timing and duration of moult in immatures replacing
different numbers of primaries. A slow moult of five or six primaries, adopted by 29%, lasted on average 98–111 days, beginning
on average 8–16 December. Moult of four primaries (63%) began on 6 January and averaged 73 days. A rapid moult of three primaries
(7%) began on 24 January and averaged 55 days. All groups ended their moult between 19 and 28 March. GLM models showed that
heavier immatures were more likely to start moulting than leaner birds. This tendency was more pronounced in November–January
than in later months. The later the moult started, the fewer feathers were replaced and the faster the process. Departure
time set the limit for the end of moult. We suggest the ability to choose different strategies allows immature Wood Sandpipers
to adjust their moult to the variable conditions they encounter at wetlands in southern Africa. 相似文献
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不同发育时期水曲柳种子的形态生理变化及其层积处理后的萌发效应 总被引:1,自引:0,他引:1
探讨不同发育时期水曲柳种子的外部形态和生理变化及其层积处理后的萌发效应结果表明:水曲柳开花120d后为成熟脱水阶段,开花110d后种子的胚长和胚乳干重趋于稳定,花后110~120d期间种子胚干重趋于稳定;花后70~100d采集的种子不耐层积,层积处理后逐渐死亡,花后110d采集的种子经层积处理后可以萌发;110d后采集的水曲柳种子经暖温(20℃)16周+低温(5℃)12周的层积处理后,其休眠破除的效果较好,适当延长暖温层积时间有利于提高种子萌发率。 相似文献
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以美洲黑杨与大青杨杂种无性系1年生扦插苗为材料,测定其低温胁迫中多个生理指标的变化。结果表明,6个杂种无性系SOD、POD和APX活性在低温胁迫中均表现出先上升后下降的趋势,而电解质渗漏率、活性氧含量、CAT和GR活性保持逐渐升高的趋势。无性系间差异显著,其中DU146和DU147电解质渗漏率和活性氧含量最低,而5种抗氧化酶活性均最高,表明其具有较强的耐寒性;而DU135和DU150电解质渗漏率和活性氧含量最高,而5种抗氧化酶活性均最低,表明其耐寒性差。 相似文献